منابع مشابه
Bacterial Protein-Tyrosine Kinases
Bacteria and Eukarya share essentially the same family of protein-serine/threonine kinases, also known as the Hanks-type kinases. However, when it comes to protein-tyrosine phosphorylation, bacteria seem to have gone their own way. Bacterial protein-tyrosine kinases (BY-kinases) are bacterial enzymes that are unique in exploiting the ATP/GTPbinding Walker motif to catalyze phosphorylation of pr...
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Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and PA are important second messengers cascading T cell receptor (TCR) signal by recruiting multiple effector molecules, such as RasGRP1, PKCθ, and mTOR. Studies have revealed important physiological fu...
متن کاملThe EspF effector – a bacterial pathogen ’ s
10 Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector 11 proteins directly into the cells of their eukaryotic host. EspF is one of many effector proteins 12 exclusive to the attaching and effacing pathogen family that includes enteropathogenic 13 (EPEC) and enterohemorrhagic E. coli (EHEC). Work in recent years has revealed EspF to be 14 one of the most m...
متن کاملType III effector proteins: doppelgangers of bacterial virulence.
Bacterial pathogens have co-evolved with their hosts in their ongoing quest for advantage in the resulting interaction. These intimate associations have resulted in remarkable adaptations of prokaryotic virulence proteins and their eukaryotic molecular targets. An important strategy used by microbial pathogens of animals to manipulate host cellular functions is structural mimicry of eukaryotic ...
متن کاملModification of Bacterial Effector Proteins Inside Eukaryotic Host Cells
Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins -called effectors- directly into the plant or animal cells. Recent findings have shown that such effectors can suffer covalent modifications inside the eukaryotic cells. Here, we summarize the recent reports where effector modifications by the eukaryotic machinery have been described. We restrict our focus o...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2014
ISSN: 2053-2733
DOI: 10.1107/s2053273314095710